Recombinant PAK1 anticorps (pSer139, pSer141, pSer144)

N° du produit ABIN7127722

Cet anticorps anti-PAK1 est un anticorps Lapin Monoclonal détectant PAK1 dans WB, IHC et ELISA. Adapté pour Humain.

Aperçu rapide pour Recombinant PAK1 anticorps (pSer139, pSer141, pSer144) (ABIN7127722)

Antigène: PAK1 (P21-Activated Kinase 1 (PAK1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PAK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 3H12

Détail du produit anti-PAK1 anticorps

Épitope: pSer139, pSer141, pSer144

Fonction: Phospho-PAK1/PAK2/PAK3 (S144+S141+S139) Recombinant Monoclonal Antibody

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human Phospho-PAK1/PAK2/PAK3 (S144+S141+S139)

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:5000, IHC:1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PAK1

Antigène: PAK1 (P21-Activated Kinase 1 (PAK1))

Autre désignation: PAK1

Sujet:

Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.

Aliases: Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-3, PAK3, OPHN3

UniProt: O75914, Q13153, Q13177

Pathways: Signalisation MAPK, Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Embryonic Body Morphogenesis